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Revolutionizing Mobile Safety: Pyrazole Derivatives Shield Neurons from 4G Radiation!

Vara Prasad Saka Dr. Vara Prasad SakaApril 7, 2024
5 1 minute read

In a groundbreaking study, researchers have unveiled the potential of pyrazole derivatives in safeguarding cortical neurons against the harmful effects of electromagnetic radiation (EMR) emitted by 4G mobile phones. This discovery comes as a beacon of hope amid rising concerns about the impact of wireless device radiation on public health.

The study, led by V. P. Saka, C. V., and D. Narayanasamy, investigated the neuronal effects of EMR on primary cortical neurons (PCNs) isolated from neonatal rat cerebral cortex. These neurons were subjected to EMR emitted by a mobile phone operating at a frequency of 2100 MHz with a specific absorption rate (SAR) of 1.6W/Kg in call-answered mode for a duration of 2 hours. However, what sets this research apart is the concurrent treatment of PCNs with hispolon (HIS) and its derivatives, shedding light on a potential avenue for mitigating EMR-induced damage.

The findings revealed a remarkable protective role of pyrazole derivatives in reducing apoptosis, the programmed cell death, triggered by EMR exposure. Through modulation of pro and anti-apoptotic genes via the mitochondrial pathway, these compounds exhibited the ability to counteract the detrimental effects of EMR on cortical neurons. Furthermore, the compounds demonstrated antioxidative properties, effectively reducing the levels of reactive oxygen species (ROS) generated by mitochondrial damage induced by EMR.

This breakthrough holds significant implications for public health, as it opens avenues for the development of neuroprotective formulations to combat the adverse effects of mobile phone radiation on neuronal health. The neuroprotective mechanisms of pyrazole derivatives warrant further investigation, offering promising prospects for their utilization as lead compounds in the development of novel therapeutic interventions.

The study, published in the prestigious journal Journal of Biochemical and Molecular Toxicology, marks a crucial step forward in understanding and addressing the challenges posed by EMR exposure from mobile phones. With the potential to revolutionize neuroprotective strategies, these findings offer a glimmer of hope in the quest for safer wireless technology usage.

For more information on this groundbreaking research, please refer to the article: https://doi.org/10.1002/jbt.23351

Stay tuned for further updates on advancements in neuroprotection and the burgeoning field of wireless technology safety.

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Vara Prasad Saka Dr. Vara Prasad SakaApril 7, 2024
5 1 minute read
Vara Prasad Saka

Dr. Vara Prasad Saka

Dr. Vara Prasad Saka is a dedicated pharmacologist with over 9.5 years of experience in experimental pharmacology and molecular biology. Holding a Ph.D. from SRM College of Pharmacy, his research focuses on neurodegenerative effects and neuroprotection related to mobile phone radiation. He has been serving as a Research Associate and Senior Research Fellow at Dr. Anjali Chatterji Regional Research Institute for Homoeopathy, leading high-quality in-vivo and in-vitro experiments. Previously, he was an Assistant Professor at Vignan Pharmacy College and Nimra College of Pharmacy, where he excelled in teaching and mentoring students. Dr. Saka is an active member of IPA and ISPOR, and he has contributed to numerous peer-reviewed journals as an editorial board member (PLOS ONE) and reviewer. His expertise includes animal handling, behavioral models, and pharmacological screening, along with proficiency in software like GraphPad Prism and SPSS.
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